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Vinnik, Vladimir ; Zhang, Fan ; Park, Hyunjun ; Cook, Taylor B. ; Throckmorton, Kurt ; Pfleger, Brian F. ; Bugni, Tim S. ; Thomas, Michael G. ( , ACS Chemical Biology)null (Ed.)
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Lott, Donovan J. ; Taivassalo, Tanja ; Cooke, Korey D. ; Park, Hyunjun ; Moslemi, Zahra ; Batra, Abhinandan ; Forbes, Sean C. ; Byrne, Barry J. ; Walter, Glenn A. ; Vandenborne, Krista ( , Muscle & Nerve)
Abstract Background This two‐part study explored the safety, feasibility, and efficacy of a mild–moderate resistance isometric leg exercise program in ambulatory boys with Duchenne muscular dystrophy (DMD).
Methods First, we used a dose escalation paradigm with varying intensity and frequency of leg isometric exercise to determine the dose response and safety in 10 boys. Second, we examined safety and feasibility of a 12‐wk in‐home, remotely supervised, mild–moderate intensity strengthening program in eight boys. Safety measures included T2MRI, creatine kinase levels, and pain. Peak strength and function (time to ascend/descend four stairs) were also measured.
Results Dose‐escalation revealed no signs of muscle damage. Seven of the eight boys completed the 12‐wk in‐home program with a compliance of 84.9%, no signs of muscle damage, and improvements in strength (knee extensors
P < .01; knee flexorsP < .05) and function (descending stepsP < .05).Conclusions An in‐home, mild–moderate intensity leg exercise program is safe with potential to positively impact both strength and function in ambulatory boys with DMD.